How do you calculate the maintenance dose of digoxin?
Maintenance dose: Digoxin clearance= [CRCL + 40] x 1.44 (add 20 instead of 40 if pt has CHF). Predicted Css= (Dose) (0.65 to 0.8)/ Digoxin clearance.
How much digoxin do you give a patient with renal insufficiency?
If pt has renal insufficiency give 6 to 10 mcg/kg IBW. A-fib: 10 to 15 mcg/kg IBW given as above. (If given IVPush-admin over at least 5 min). Maintenance dose: Digoxin clearance= [CRCL + 40] x 1.44 (add 20 instead of 40 if pt has CHF).
How many doses of digoxin are in digoxin and Elixir?
250 mcg (0.25 mg) doses of Digoxin Tablets and Elixir Pediatric, respectively (see Table 1 in CLINICAL PHARMACOLOGY: Pharmacokinetics ). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
What is the difference between once-daily and twice-daily doses of digoxin?
On a once-daily dosing schedule, the concentration of digoxin will be 10% to 25% lower when sampled at 24 versus 8 hours, depending upon the patient’s renal function. On a twice-daily dosing schedule, there will be only minor differences in serum digoxin concentrations whether sampling is done at 8 or 12 hours after a dose.
What are the precautions for the administration of digoxin?
-Inject over 5 minutes or longer and avoid bolus administration. -If tuberculin syringes are used to measure very small doses, do not flush the syringe with the parenteral solution after the syringe contents are expelled into an indwelling vascular catheter to avoid over administration of digoxin. Storage requirements: Protect from light.
What is the distribution of digoxin in the body?
Distribution: only a small fraction of digoxin in present in blood (little is removed by hemodialysis). Digoxin distributes very little into body fat–doses must be based on lean body weight. Distribution is not altered by obesity. There appears to be a gradual contraction in the volume of distribution as renal function deteriorates.