What do sulfotransferases do?

What do sulfotransferases do?

Sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group from a donor molecule to an acceptor alcohol or amine.

What is SULT enzyme?

The superfamily of sulfotransferase (SULT) enzymes catalyzes the sulfate conjugation of several pharmacologically important endo- and xenobiotics. SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and p-nitrophenol (PNP).

What is Sulfotransferase enzyme?

Sulfotransferases are enzymes that catalyze the transfer of sulfo groups from a donor, for example 3′-phosphoadenosine 5′-phosphosulfate, to an acceptor, for example the amino or hydroxyl groups of a small molecule, xenobiotic, carbohydrate, or peptide.

Where are Sulfotransferases found?

the Golgi
PAPS is a cosubstrate and source of activated sulfate for both cytosolic sulfotransferases and carbohydrate sulfotransferases, which are located in the Golgi.

What is sulfation in metabolism?

Sulfation is an important pathway of metabolism for a range of endogenous compounds including steroid hormones, bile acids, neurotransmitters, and small peptides. Xenobiotics also undergo conjugation by sulfation, which generally, but not exclusively, leads to reduced biological activity.

What is the cofactor for Sult?

The formation of the latter species is catalyzed by sulfotransferases (SULTs), which for their activity depend on the cofactor 3′-phosphoadenosine-5′-phosphosulfate (PAPS).

What is sulfation in biology?

What is meant by sulfation?

[ sŭl-fā′shən ] n. The addition of sulfate groups as esters to molecules.

What is the meaning of sulfated?

1 : a salt or ester of sulfuric acid. 2 : a divalent group or anion SO4 characteristic of sulfuric acid and the sulfates. sulfate. verb. sulfated; sulfating.

What is phase 2 enzymes?

Phase 2 enzymes traditionally refer to the enzymes catalyzing the conjugation reactions, such as glutathione S-transferase (GST), UDP-glucuronosyltransferase ( UGT), N-acetyltransferase (NAT), and sulfotransferase (SULT).

What does Desulfation mean in chemistry?

The lead sulfate crystals are broken down (more or less successfully) in the charge cycle. Sometimes some crystals remain, or sometimes a battery is left partially discharged where the crystals of lead sulfate harden, and reduce the capacity of the battery to be charged. This is what desulfation (desulphation)is about.

What does sulfation mean in chemistry?

sulfation, also spelled Sulphation, in chemistry, any of several methods by which esters or salts of sulfuric acid (sulfates) are formed. The esters are commonly prepared by treating an alcohol with sulfuric acid, sulfur trioxide, chlorosulfuric acid, or sulfamic acid.

What is Sulfoconjugation?

SUMMARY Sulfoconjugation is an important metabolic pathway determining the fate and poten- tial cardiovascular action of ingested phenolic substances. Among the three catecholamines, dopa- mine (DA) is to the highest degree sulfoconjugated and has the highest affinity toward the phenolsulfo- transferase (PST).

What is Desulfation mode?

Desulfation mode is a battery slitter unique technique that can help a lot in the recovery of the battery. However, there are certain things you have to take care of whenever you are trying to go for the desulfation mode of the battery. Applying Voltage.

What is another word for sulfates?

In this page you can discover 16 synonyms, antonyms, idiomatic expressions, and related words for sulphate, like: sulfate, dichromate, hydroxide, chloride, cupric, phosphate, molybdate, ferric, ammonium, magnesium and hcl.

What are sulfotransferases?

Sulfotransferases ( SULTs) are transferase enzymes that catalyze the transfer of a sulfo group from a donor molecule to an acceptor alcohol or amine. The most common sulfo group donor is 3′-phosphoadenosine-5′-phosphosulfate (PAPS).

What is the structure of 3o-sulfotransferase?

3-O-sulfotransferase. The SULT crystal structures have shown that the enzymes are generally globular proteins with a single α/β domain that forms characteristic five-stranded parallel β-sheet surrounded on either side with α-helices ( Fig. 2 ). The β-sheets contribute the PAPS-binding site and the core catalytic residues.

How is human sulfotransferase SULT1A1 regulated?

The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein. Mol. Pharmacol. –1701. ). Human sulfotransferase SULT 1C1: cDNA cloning, tissue-specific expression, and chromosomal localization. –470.

What drives the interindividual variation in sulfotransferase activity in humans?

While some of the marked interindividual variation in sulfotransferase activity in the human population (5- to 36-fold) can be explained by polymorphisms in the coding regions of SULT genes ( Pacifici and Coughtrie, 2005; Pacifici and De’Santi, 1995), variations in regulatory regions have not been fully explored.